Journal article
Control of Neuronal Survival and Development Using Conductive Diamond
S Falahatdoost, YDJ Prawer, D Peng, A Chambers, H Zhan, L Pope, A Stacey, A Ahnood, HN Al Hashem, SE De León, DJ Garrett, K Fox, MB Clark, MR Ibbotson, S Prawer, W Tong
ACS Applied Materials and Interfaces | AMER CHEMICAL SOC | Published : 2024
Abstract
This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular-substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neur..
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Awarded by RMIT University
Funding Acknowledgements
This research was funded by a Medicine/Science Grant from the CASS Foundation (CASS 8612), a Linkage Grant from the Australian Research Council (LP180100638), and a grant from the Australian College of Optometry. A.A. was supported by a Discovery Project from the Australian Research Council (DP210102750). M.B.C. was supported by National Health and Medical Research Council (APP11968410). W.T. was supported by a University of Melbourne Early Career Researcher Grant (2021ECR091) and a Discovery Early Career Researcher Award (DECRA) Fellowship from The Australian Research Council (DE220100302).